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KMID : 0352419910100010078
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Keimyung Medical Journal
1991 Volume.10 No. 1 p.78 ~ p.88
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IAPP does not Cause Peripheral or Hepatic Insulin Resistance in Conscious Dogs, but does have a Hypocalcemic Effect
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:A. A. Kassir
:A. K. Upadhyay/:Lim T. J./:A. R. Moossa/:J. M. Olefsky
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Abstract
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In this study we have administered constant intravenous infusions of IAPP, to conscious dogs during the euglycemic glucose clamp setting. The doses of IAPP used (5 and 50 pmol/kg/min) raised the circulating IAPP levels approxomately 12-fold and 50-fold above basal, respectively. Studies were conducted at two differnet insulin infusion rates, resulting in steady state plasma insulin levels of ∼610 and 2600 pmol. our results showed that the IAPP infusions did not lead to any measurable change in the insulin stimulated glucose disposal rate, at either insulin infusion rate. Additionally, no effect of IAPP on hepatic glucose production was observed. Intravenous glucose tolerance tests were also performed with and without a concomitant IAPP infusion and we found that IAPP had no influence on the glucose profile. Aithough we could not observe any effect of IAPP on any of the measured aspects of glucose or insulin metabolism, we did find a consistent hypocalcemic effect of this perptide. Shortly after the onset if IAPP on any of the measured aspects of glucose or insulin metabolism, we did find a consistent hypocalcemic effect of this peptide. Shortly after the onset of IAPP infusion. serum calcium levels fell by 10-15% and remained at these levels throughout the coures of the IAPP infusion. In summary: (1) infusion of IAPP at doses of 5 or 50 pmol/kg/min in conscious dogs raises the circulating IAPP level 12-to 50-fold above basal (2) During these infusion studies, no effect of IAPP was observed on any of the measured aspectes of glucose or insulin homeostasis. (3) IAPP leads to a prompt reduction in plasma calcium concentrations upon intravenous administration.
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